| Title |
Dopaminergic neurotrophins and astroglial-neuronal interactions in the rat ventral mesencephalon / by Terri Wood. |
|
| Special Collections on Request
|
DP2004 WOOD |
LIB USE ONLY |
|
|
| Dissertation |
Thesis (Ph.D.) --NUI, 2004 at Department of Anatomy, UCC. |
| Summary |
Parkinson's disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Neurotrophins such as growth differentiation factor-5 (GDF-5) and glial cell line-derived nuerotrophic factor (GDNF) have proven to have potent effects on dopaminergic neurons and may have therapeutic potential in the treatment of this disease. This study investigated the possible involvement of glia in the neurotrophic effect induced by GDF-5 on embryonic rat midbrain dopaminergic neurons and the effect of glia-depletion on these neurons in vitro. The effect of GDF-5 and GDNF either alone or in combination on dopaminergic neuronal and glial cell survival in these cultures was investigated. |
| Subject |
Rats.
|
|
Central nervous system.
|
| Collection |
Theses Ph.D.
|
|
Theses Anatomy Department
|
| Description |
225 p. : ill. ; 30 cm. |
|
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